Research has shown that levels of empathy begin to decline early during medical training, often after the first year of medical school. This negatively impacts provider well-being, patient experience, and patient safety and outcomes. The culture of medicine includes many powerful obstacles to individual self-care and organizational change. Many trainees are already skeptical and hopeless that meaningful change is possible. Ending burnout and ensuring well-being among residents requires a multi-faceted, multi-disciplinary approach that includes initiatives over both short and long-term time horizons, which can be challenging to initiate.