Early diagnosis and intervention for amyloidosis is critical yet does not frequently occur, typically as a consequence of the insidious nature of the disease, phenotypic heterogeneity, and limited awareness on the part of clinicians. Therapeutic options have previously been limited, but there are new and emerging agents with which clinicians may not be familiar. Patients with amyloidosis have many unmet needs, including delayed diagnosis. PCPs can help meet this need through timely recognition and referral of patients with suspected amyloidosis to specialists.